JP/EN

Syllabus

SubjectSPECIAL RESEARCH PROJECT B （ポリケチド）

Class Information

Faculty/Graduate School
POLICY MANAGEMENT / ENVIRONMENT AND INFORMATION STUDIES
Course Registration Number
48960
Subject Sort
A1202
Title
SPECIAL RESEARCH PROJECT B
Field
Research Seminars
Unit
2 Unit
Year/Semester
2022 Spring
K-Number
FPE-CO-05203-411-88
Research Seminar Theme

Function and structural analysis of polyketide synthases

Year/Semester
2022 Spring
Day of Week・Period
Lecturer Name
Masaru Tomita
Class Format
Face-to-face
Language
Japanese
Location
TTCK
Class Style
＊Please click here for more information on the correspondence between 'Class Style' and ’Active Learning Methods’.
Lab / On-site Training / Skill-Development, Connecting to Other Sites
GIGA Certificate
Not applied
Research Seminar / Project Theme planned for next semester

Detail

Course Summary

Modular polyketide synthase (PKSs) synthesize the core structures of diverse natural products, including antibiotics and immunosuppressants. However, since modular PKSs are huge enzyme, their entire protein structures have not yet determined. Here, by first predicting the structure of the protein using AlphaFold2, we will confirm how the structural difference occurs in all PKSs whose three-dimensional structure has been determined. In addition, we will analyze the expression and function of proteins that visualize the structure.