In this lecture, we study on numerical analysis with python scripting language. We use Numpy, Scipy and Sympy library for numerical analysis. We analysis the real numerical data values including image data and audio data. The lecture introduces the concept and the algorithm for numerical analysis and then students make the program by themselves or with the libraries. The following items will be studied; the equation solving, the operations on matrices and vectors, the solutions of linear equation using Gaussian elimination, Fast Fourier Transform, regression analysis, interpolation, numerical integration, approximate solution of ordinary differential equation. While the level of the mathematical contents of this lecture is based on the mathematics for science course in university, the programming level is easier than the contents. We start this lecture with revising the Python scripting language briefly.