Biology has transformed into a data-driven science, due to the advent of numerous high-throughput measurement technologies. Central to these innovations is the genetic information. One of the core properties of living systems is the existence of genetic information, and analysis of this information, is the central challenge of bioinformatics. Moreover, analysis of genes and genomes through bioinformatics is basically an informatics problem. In this course, major software tools and algorithms for searching, comparison, assembly, variation detection, quantification of genetic sequences would be covered, with hands-on workshops, to understand the basics of genome and bioinformatic analyses.