For more than half a century now, a genome has been a blueprint for the mystery of life. The genome has been treated as one of the primary information in molecular biology. Several technological innovations have drastically reduced the amount of effort spent on determining the genome sequences. Then, "how to use it" has become more important than observing a string of letters. At the same time, however, people have been faced with the difficulty of truly understanding the information written in the genome sequence. The genome is a blueprint, describing all the information that governs the phenomena of life. However, a great deal of further experimentation and verification is required to understand the life systems generated by the interaction of genomic elements. A separate understanding of genome information cannot help us to know the interlocking biological phenomena. This course is designed to provide a systematic introduction to the origins of genomics, the principles of genome designing biology, designable parameters, and usage of the genome. Furthermore, we will discuss and consider the issues that need to addressed to realize the genome designing biology.